NBDC Research ID: hum0061.v1

SUMMARY

Aims: To identify causative genetic aberrations in multiple primary lung cancer

Methods: Whole exome sequencing (Illumina HiSeq 2000)

Participants/Materials: Siblings developed multiple primary lung cancers

Dataset ID	Type of Data	Criteria	Release Date
JGAS000057	NGS (Exome)	Controlled-access (Type I)	2017/02/20

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MOLECULAR DATA


Participants/Materials	Siblings developed multiple primary lung cancers
Targets	Exome
Target Loci for Capture Methods	-
Platform	Illumina [HiSeq 2000]
Library Source	gDNA extracted from peripheral blood cells of siblings developed multiple primary lung cancers
Cell Lines	-
Library Construction (kit name)	BGI exome sequencing service
Fragmentation Methods	BGI exome sequencing service
Spot Type	Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers)	90 bp
Japanese Genotype-phenotype Archive Dataset ID	JGAD000057
Total Data Volume	29 GB 　　Data files: 8 (fastq) 　　Analysis files: 4 (vcf [ref: hg19])
Comments (Policies)	NBDC policy

Principal Investigator: Kikuya Kato

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases

Project / Group Name: -

Funds / Grants (Research Project Number):

Name	Title	Project Number
KAKENHI Grant-in-Aid for Scientific Research (C)	Identification of causative genes for hereditary cancer by genome analyses of familial cancer cases and its application	25430180
The Osaka Community Foundation	Searching causative genes of familial or sporadic rare tumors using whole gene sequencing	-
The Charitable Trust Osaka Cancer Research Foundation	Searching causative genetic aberrations of familial or sporadic rare tumors by genome analyses of patients	-
The Osaka Medical Research Foundation for Intractable Diseases	Searching causative genes of familial cancers by genome analyses of sibling patients with rare cancer	-

	Title	DOI	Dataset ID
1	Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs	doi: 10.1101/mcs.a001032	JGAD000057
2

Principal Investigator	Affiliation	Country/Region	Research Title	Data in Use (Dataset ID)	Period of Data Use
Hirofumi Nakaoka	Department of Cancer Genome Research, Sasaki Institute	Japan	Genetic analysis of lung cancer	JGAD000057	2022/08/06-2023/03/31