NBDC Research ID: hum0250.v1
SUMMARY
Aims： Compare the functional MRI data with amyloid PET images and cognitive data and establish a methodologies for the very early stage of Alzheimer disease (AD).
Methods： Structural MRI, resting state functional MRI, diffusion tensor imaging, and arterial spin labeling will be acquired
Participants/Materials: Mild cognitive impairment (MCI) and preclinical AD individuals (ICD10: F00)
URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020292
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000277 | Psychometric Tests, MRI Scan (3T), PET Scan (Amyloid [11C-PiB]) | Controlled-access (Type I) | 2021/03/29 |
* Restrictions on data use：NBDC policy
*Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more
Data Summary
Dataset ID: JGAD000383 (19.2 GB)
Psychometric Tests
| CRF Name | CRF Description | File Name | File Format（Extension） |
|---|---|---|---|
| CDA*1 | Clinical Dementia Rating | CLINICAL.xlsx | Exel (.xlsx) |
| MMSE*2 | Mini Mental State Exam | ||
| WMS-R LM-Ⅰ&Ⅱ Story A*3 | Wechsler Memory Scale-Revised Logical MemoryⅠ&Ⅱ Story A | ||
| FCSRT*4 | Free and Cued Selective Recall Test | ||
| DSST*5 | Digit Symbol Substitution Test |
※1：Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982 Jun;140:566-72. PMID 7104545
※2：Folstein, MF; Folstein, SE; McHugh, PR (1975). ""Mini-mental state". A practical method for grading the cognitive state of patients for the clinician". Journal of Psychiatric Research 12 (3): 189–98. PMID 1202204
※3： Wechsler D (1987) Wechsler Memory Scale-Revised. San Antonio, TX Psychological Corporation.
※4： Grober E, Buschke H, Crystal H, Bang S, Dresner R (1988) Screening for dememtia by memory testing. Neurology 38:900-903 PMID 3368071
※5： Wechsler D (1997) Wechsler Adult Intelligence Scale-Third Edition. San Antonio: The Psychological Corporation
MRI scan (3T) Images
| CRF Name | CRF Description | File Name | File Format（Extension） |
|---|---|---|---|
| MPRAGE/IRSPGR | magnetization prepared rapid gradient echo/inversion recovery spoiled gradient echo | Bm-nnn_MRI.zip (nnn: de-identified ID) | DICOM |
| 3D FLAIR | three-dimensional fluid attenuated inversion recovery | ||
| High resolution T2WI | high-resolution T2 weighted image | ||
| fMRI | functional MRI | ||
| ASL | arterial spin labeling | ||
| DTI | diffusion tensor imaging |
※ See J-ADNI_MRIQC_Ver1.1.pdf and MRI Scanner list for MRI quality control procedures
PET Scan (Amyloid [11C-PiB]) Images
| Description | File Name | File Format（Extension） |
|---|---|---|
| PET Images（Post-processed） | Bm-nnn_PET.zip (nnn: de-identified ID) | DICOM |
※ See J-ADNI_PETQC_Ver1.1.pdf and PET Scanner list for PET quality control procedures.
DATA PROVIDER
Principal Investigator: Takeshi Iwatsubo
Affiliation: Department of Neuropathology, Graduate School of Medicine, the University of Tokyo
Project / Group Name: Brain Mapping by Integrated Neurotechnologies for Disease Studies
URL： https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000020292
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS), Japan Agency for Medical Research and Development (AMED) | Identification of damaged neuronal circuits in very early Alzheimer disease patients and elucidation of molecular mechanism of tau pathology spreading | JP18dm0207014 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 |
USERS (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
| Mikihiro Yasuda | Kwansei Gakuin University | Japan | Construction of a method for analyzing brain networks based on fMRI data | JGAD000383 | 2023/08/25-2025/03/31 |
