NBDC Research ID: hum0136.v1

 

SUMMARY

Aims: To identify host genetic factors associated with response to a HB vaccination

Methods: Genome-wide association study

Participants/Materials: 1,193 Japanese individuals vaccinated with a HB vaccine

 

Data Set IDType of DataCriteriaRelease Date
hum0136.v1.gwas.v1 GWAS for 1,193 Japanese individuals vaccinated with a HB vaccine Un-restricted Access 2018/05/22

*Release Note

 

MOLECULAR DATA

hum0136.v1.gwas.v1

Participants/Materials

1,193 Japanese individuals vaccinated with a HB vaccine

    - Low responders (n=107, HBsAb ≤ 10mIU/mL)

    - Intermediate responders (n=351, 10mIU/mL < HBsAb ≤ 100mIU/mL)

    - High responders (n=735, HBsAb >100mIU/mL)

864 Japanese individuals under the age of 30 years vaccinated with a HB vaccine

    - Low responders (n=56, HBsAb ≤ 10mIU/mL)

    - Intermediate responders (n=226, 10mIU/mL < HBsAb ≤ 100mIU/mL)

    - High responders (n=582, HBsAb >100mIU/mL)

Targets genome wide SNPs
Target Loci for Capture Methods -
Platform Affymetrix [Axiom Genome-Wide ASI 1 Array]
Library Source DNAs extracted from peripheral blood cells
Cell Lines -
Reagents (Kit, Version) Affymetrix AXIOM 2.0 Reagent Kit
Genotype Call Methods (software) GenCall software (Genotyping Console ver. 4.2.0.26)
Filtering Methods

overall call rate < 0.95, SNP call rate < 0.95,

HWE P < 0.001, MAF < 0.05, Regression P < 0.05

Marker Number (after QC)

I. Regression analysis for low (0), intermediate (1), and high (2) responders (covariates: age nad gender): 22,044 SNPs (hg19) [Figure 2]

II. Regression analysis for low (0), intermediate (1), and high (2) responders under the age of 30 years (covariates: age nad gender): 21,580 SNPs (hg19) [Supplementary Figure 4]

III. Regression analysis for low (0) and high (1) responders (covariates: age nad gender): 23,765 SNPs (hg19) [Supplementary Figure 4]

NBDC Data Set ID

hum0136.v1.gwas.v1

(Click the Data Set ID to download the file)

Dictionary file

Total Data Volume 7.3 MB
Comments (Policies) NBDC policy

*When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more

 

DATA PROVIDER

Principal Investigator: Masashi Mizokami

Affiliation: Natinal Center for Global Health and Medicine

Project / Group Name: Genome Medical Science Project

URL: http://www.ncgmkohnodai.go.jp/genome/english/index.html

Funds / Grants (Research Project Number):

NameTitleProject Number
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for an Integrated Database of Clinical and Genomic Information Construction of integrated clinical genome database regarding hepatitis B related diseases JP16kk0205007
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program for Basic and Clinical Research on Hepatitis Identification of genes associated with hepatitis B virus-related diseases by genome-wide analyses 16fk021010h0001
Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science Program on the Innovative Development and the Application of New Drugs for Hepatitis B Elucidation of the pathogenesis for HBV clearance, chronic hepatitis B infection, and hepatocellular carcinoma JP17fk0310115
KAKENHI Grant-in-Aid for Scientific Research (C) Comprehensive understanding for the relationship between HLA class II genes and chronic hepatitis B infection 16K09387

 

PUBLICATIONS

TitleDOIData Set ID
1 Key HLA‐DRB1‐DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine doi: 10.1002/hep.29876 hum0136.v1.gwas.v1
2