## 2018 age-at-menopause GWAS result in the Biobank Japan Project ### Descrption: This is a summary file for results of GWAS for age-at-menopause in the Biobank Japan Project released via National Bioscience Database Center (NBDC). - Research ID: hum0014 - Date of release: 2018/08/07 ### Uploaded files: | File name | Number of samples | Number of variants | |-----------------------------------------|-------------------|--------------------| | 2018_BBJ_Menopausee_GWAS.rv.txt | 43,861 | 9,296,729 | ### Columns: | Column number | Header | Description | |---------------|----------------------|-----------------------------| | 1 | MARKER | marker name | | 2 | CHR | chromosome | | 3 | POS | position (hg19) | | 4 | EFFECT_ALLELE | effect allele | | 5 | NON_EFFECT_ALLELE | other allele | | 6 | EFFECT_ALLELE_FREQ | effect allele frequency | | 7 | INFO | imputation quality | | 8 | BETA | effect estimate | | 9 | SE | standard error | | 10 | P | P-value | | 11 | N | sample size | ・ Variants with imputation quality (minimac r2)<0.3 or minor allele frequency <0.5% are removed. ・ Association analysis was performed using mach2qtl software (Li Y. et al, Genet. Epidemiol. 2010). ### Link: [The biobank Japan project](https://biobankjp.org/english/index.html) [National Bioscience Database Center Human Database](https://humandbs.biosciencedbc.jp/en/) [RIKEN Center for Integrative Medical Sciences](http://www.ims.riken.jp/english/) ### Reference: If you use these data, please cite the following paper: Horikoshi M et al. Elucidating the genetic architecture of reproductive ageing in the Japanese population. Nat Commun (2018). doi: 10.1038/s41467-018-04398-z