NBDC Research ID: hum0126.v2
SUMMARY
Aims: To identify the novel disease susceptibility genes for Childhood Idiopathic Nephrotic Syndrome
Methods: GWAS
Participants/Materials: Healthy controls and Childhood Idiopathic Nephrotic Syndrome patients
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| hum0126.v1.gwas.v1 | GWAS for 224 Childhood Idiopathic Nephrotic Syndrome patients and 419 healthy adult controls | Unrestricted-access | 2018/04/27 |
| hum0126.v2.imp-gwas.v1 | GWAS for 3,206 Childhood Idiopathic Nephrotic Syndrome patients and 987 healthy adult controls | Unrestricted-access | 2020/09/01 |
*When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more
MOLECULAR DATA
| Participants/Materials | 224 Childhood Idiopathic Nephrotic Syndrome patients (ICD10: N049) and 419 healthy adult controls |
| Targets | genome wide SNPs |
| Target Loci for Capture Methods | - |
| Platform | Affymetrix [Japonica Array v1] |
| Library Source | DNAs extracted from peripheral blood cells |
| Cell Lines | - |
| Reagents (Kit, Version) | Axiom 2.0 Reagent kit |
| Genotype Call Methods (software) | Axiom Analysis suite 1.0.0.3 |
| Filtering Methods | Sample Call rate < 0.97, SNP call rate < 0.97, HWE P < 0.0001, MAF < 0.05 |
| Marker Number (after QC) | 495,887 SNPs (hg19) |
| NBDC Dataset ID |
(Click the Dataset ID to download the file) |
| Total Data Volume | 11.6 MB |
| Comments (Policies) | NBDC policy |
| Participants/Materials | 987 Childhood Idiopathic Nephrotic Syndrome patients (ICD10: N049) and 3,206 healthy adult controls |
| Targets | genome wide SNPs |
| Target Loci for Capture Methods | - |
| Platform | Affymetrix [Japonica Array v1 / v2] |
| Library Source | DNAs extracted from peripheral blood cells |
| Cell Lines | - |
| Reagents (Kit, Version) | Axiom 2.0 Reagent kit |
| Genotype Call Methods (software) | Axiom Analysis suite 1.0.0.3 |
| Filtering Methods |
Sample Call rate < 0.97, SNP call rate < 0.97, HWE P < 0.0001, MAF < 0.05 Imputation quality (Rsq) < 0.5 |
| Marker Number (after QC) | 6,834,340 SNPs (hg19) |
| NBDC Dataset ID |
(Click the Dataset ID to download the file) |
| Total Data Volume | 459 MB |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Kazumoto Iijima
Affiliation: Department of Pediatrics, Kobe University Graduate School of Medicine
Project / Group Name: The Research Consortium on Genetics of Childhood Idiopathic Nephrotic Syndrome in Japan
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED) | Identification of disease susceptible genes and drug sensitive genes in childhood nephrotic syndrome | JP17km0405108 |
| KAKENHI Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)) | Joint International Research for identification of disease-susceptible genes and drug-sensitive genes in childhood nephrotic syndrome | 18KK0244 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Strong Association of the HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population. | doi: 10.1681/ASN.2017080859 | hum0126.v1.gwas.v1 |
| 2 | Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome. | doi: 10.1016/j.kint.2020.05.029 | hum0126.v2.imp-gwas.v1 |
