NBDC Research ID: hum0124.v1

SUMMARY

Aims: Identification of the genes associated with epidermal growth factor receptor (EGFR)-mutant lung cancer

Methods: exome sequencing

Participants/Materials: lung cancer patients with EGFR-mutants

Data Set ID	Type of Data	Criteria	Release Date
JGAS000129	NGS (Exome)	Controlled Access (Type I)	2018/04/06

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MOLECULAR DATA


Participants/Materials	EGFR-mutant lung cancer (ICD10: C34): 3 cases (in 1 family)
Targets	Exome
Target Loci for Capture Methods	-
Platform	Illumina [HiSeq 2000]
Library Source	DNAs extracted from peripheral blood cells
Cell Lines	-
Library Construction (kit name)	SureSelect Target Enrichment System Human All Exon V2
Fragmentation Methods	Ultrasonic fragmentation (Covaris)
Spot Type	Single-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers)	50 bp
Japanese Genotype-phenotype Archive Data set ID	JGAD000140
Total Data Volume	9 GB (bam [ref: hg18])
Comments (Policies)	NBDC policy

Principal Investigator: Toshiaki Kikuchi

Affiliation: Niigata University Graduate School of Medical and Dental Sciences

Project / Group Name: Department of Respiratory Medicine and Infectious Diseases

Funds / Grants (Research Project Number):

Name	Title	Project Number
Project for Development of Innovative Research on Cancer Therapeutics (P-DIRECT)	Genetic background on carcinogenic mechanisms of EGFR-mutant lung cancer	15cm0106073h0005
KAKENHI Grant-in-Aid for challenging Exploratory Research	Molecular genetics of EGFR-mutant lung cancer	24659399

	Title	DOI	Data Set ID
1	Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer.	doi: 10.1111/cas.13233	JGAD000140
2

Principal Investigator:	Affiliation:	Data in Use (Data Set ID)	Period of Data Use