NBDC Research ID: hum0076.v1
SUMMARY
Aims: Genome-wide search for susceptibility genes to primary biliary cholangitis (PBC)
Methods: SNP-based genome-wide association study
Participants/Materials: 487 PBCs and 476 healthy controls
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| hum0076.v1 | GWAS | Unrestricted-access | 2016/10/05 |
*When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more
MOLECULAR DATA
| Participants/Materials |
487 PBCs 476 healthy controls |
| Targets | genome wide SNPs |
| Target Loci for Capture Methods | - |
| Platform | Affymetrix [Axiom Genome-Wide ASI 1 Array] |
| Library Source | gDNA extracted from peripheral blood cells |
| Cell Lines | - |
| Reagents (Kit, Version) | AXIOM 2.0 Reagent Kit |
| Genotype Call Methods (software) | GenCall software (Genotyping Console ver. 4.2.0.26) |
| Filtering Methods | Sample Call rate < 0.97, SNP call rate < 0.95, HWE P < 0.001, MAF < 0.05 |
| Marker Number (after QC) | 425,736 SNPs (hg19) |
| NBDC Dataset ID |
(Click the Dataset ID to download the file) |
| Total Data Volume |
55 MB |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Minoru Nakamura
Affiliation: Clinical Research Center, National Hospital Organization (NHO) Nagasaki Medical Center
Project / Group Name: PBC Consortium in Japan (PBCCJP)
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (C) | New clinical classification and the criteria for predicting long-term outcome in primary biliary cirrhosis | 20590800 |
| KAKENHI Grant-in-Aid for Scientific Research (C) | Genome-wide association study to detect disease-associated genes in Japanese patients with primary biliary cirrhosis | 23591006 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population | doi: 10.1016/j.ajhg.2012.08.010 | hum0076.v1.gwas.v1 |
