NBDC Research ID: hum0043.v1



Aims: Japanese ADNI aims to establish imaging and biofluid markers that can predict and monitor the progression of changes in the brains of elderly individuals with AD, mild cognitive impairment (MCI) or normal cognition, and eventually be used as a surrogate markers for the clinical trials of DMDs for AD.

Methods: The research protocol includes structural MRI analysis, FDG and amyloid PET, CSF sampling, apoE genotyping, combined with a set of clinical and psychometric tests that were prepared to achieve the highest compatibility to those used in US-ADNI.

Participants/Materials::Participants enrolled in a longitudinal study: 537 (healthly elderly controls: 149, mild cognitive impairment (MCI): 234, Alzheimer's disease (AD): 154)


Data Set IDType of DataCriteriaRelease Date



Clinical and Psychometric Tests, Special Mention, Biochemical Tests, MRI Scan (1.5T, 3T), PET Scan (FDG, Amyloid (PIB, BF227))

(Type I)




List of Downloadable Files

Un-restricted Access




Data Dictionary(Description of each field in table data)

Un-restricted Access




Quality Control Procedures for MRI

Un-restricted Access




Quality Control Procedures for PET

Un-restricted Access


* Release Note

* Restrictions on data use:NBDC policy

* Data users need to apply the Form 2 (Application Form for Using NBDC Human Data) to reach the Controlled Access Data. Learn more

* There is a special mention on a small portion of participants. Please make sure of it before use. Records of the participants are marked for attention in the "s.m." column of table data.

* When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more

* Citation on publication for scientific papers using J-ADNI data.


Data Summary

Data Set ID: JGAD00000000051


1.Clinical and Psychometric Tests

CRF NameCRF DescriptionFile Name File Format(Extension)ZIP File Name
ADAS*1 ADAS-Cognitive Behavior ADAS_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
ADASSCORES ADAS Sub-Scores and Total Scores ADASSCORES_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
ADSXLIST Diagnosis and Symptoms Checklist ADSXLIST_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
ARM Diagnosis/Scan Category Assignment ARM_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
BLCHANGE Diagnostic Summary - Baseline Changes BLCHANGE_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
BLSCHECK Baseline Symptoms Checklist BLSCHECK_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
CDR*2 Clinical Dementia Rating CDR_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
CONVERSIONS Conversions Confirmed by Conversion Committee CONVERSIONS_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
EXCLUSIO Exclusion Criteria EXCLUSIO_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
FAQ*3 Functional Assessment Questionnaire FAQ_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
FHQ Family History Questionnaire FHQ_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
GDSCALE*4 Geriatric Depression Scale GDSCALE_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
INCLUSIO Inclusion Criteria INCLUSIO_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
MEDHIST Medical History MEDHIST_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
MMSE*5 Mini Mental State Exam MMSE_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
MODHACH*6 Modified Hachinski MODHACH_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
NEUROBAT Neuropsychological Battery NeuroBAT_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
NEUROEXM Neurological Exam NEUROEXM_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
NPIQ*7 Neuropsychiatric Inventory Q NPIQ_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
PDXCONV Diagnostic Summary PDXCONV_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
PHYSICAL Physical Exam PHYSICAL_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
PTDEMOG Participant Demographic Information PTDEMOG_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
RECFHQ Family History Questionnaire Subtable RECFHQ_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
REGISTRY Registry REGISTRY_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
TREATDIS Early Discontinuation and Withdrawal TREATDIS_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip
VITALS Vital Signs VITALS_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_cognitive.zip

※1:Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. The American Journal of Psychiatry. 1984;141(11):1356–1364. PMID 6496779

※2:Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982 Jun;140:566-72. PMID 7104545

※3:Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37:323–329. PMID 7069156

※4:Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982-83;17(1):37-49. PMID 7183759

※5:Folstein, MF; Folstein, SE; McHugh, PR (1975). ""Mini-mental state". A practical method for grading the cognitive state of patients for the clinician". Journal of Psychiatric Research 12 (3): 189–98. PMID 1202204

※6:Hachinski VC. Multi-infarct dementia: a cause of mental deterioration in the elderly. Lancet. 1974;2:207–9. PMID 4135618

※7:Cummings, J., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994). The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology, 44, 2308-2314. PMID 7991117


2.Special Mention

ContentsFile NameFile Format(Extension)
Multidomain Amnestic MCI SpecialMention.xlsx Microsoft Excel (.xlsx)
Exceptional Enrollement SpecialMention.xlsx Microsoft Excel (.xlsx)
Delayed Interval for LMII SpecialMention.xlsx Microsoft Excel (.xlsx)
Exceptional Use of Prohibited Drugs SpecialMention.xlsx Microsoft Excel (.xlsx)
Cases Converted Twice SpecialMention.xlsx Microsoft Excel (.xlsx)
Additional Comments on Consent SpecialMention.xlsx Microsoft Excel (.xlsx)


3.Biochemical Tests

CRF NameCRF DescriptionFile Name File Format(Extension)ZIP File Name
APOE ApoE Genotyping APOE_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_biochemical.zip
BLOOD Perpheral Blood BLOOD_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_biochemical.zip
BLOOD_EXAMITEM Explanation and Normal Values of Examination Item in BLOOD BLOOD_EXAMITEM_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_biochemical.zip
CSF Cerebrospinal Fluid (CSF) CSF_J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_biochemical.zip


4.MRI scan (1.5T, 3T)

4.1 Quality Control

CRF NameCRF DescriptionFile Name File Format(Extension)ZIP File Name
MRIQC MRI Scan Information MRIQC-J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_mriqc.zip

※ See J-ADNI_MRIQC_Ver1.1.pdf and MRI Scanner list for MRI quality control procedures

4.2 MRI Images

Directory NameDescriptionFile Name File Format(Extension)ZIP File Name
Original Raw MRI Images obtained from MRI Scanners See File_list_J-ADNI.pdf Neuroimaging Informatics Technology Initiative (NIfTI) image file format (.nii) JADNI####_mri.zip
DistortionCorrected Distortion in the raw MRI Image was corrected by using methods developed in J-ADNI project See File_list_J-ADNI.pdf Neuroimaging Informatics Technology Initiative (NIfTI) image file format (.nii) JADNI####_mri.zip

4.3 FreeSurfer Analysis

Analysis DescriptionFile Name File Format(Extension)ZIP File Name
Subcortical Segmentation containing the Volumes of Specific Structures aseg.stats Tab Separated Variables JADNI_freesurfer.zip
Cortical Parcellation containing Thickness of Specific Structures based on Destrieux Atlas lh.aparc.a2009s.stats(Left Hemisphere)
rh.aparc.a2009s.stats(Right Hemisphere)
Tab Separated Variables JADNI_freesurfer.zip
Cortical Parcellation containing Thickness of Specific Structures based on Desikan-Killiany Atlas lh.aparc.stats(Left Hemisphere)
rh.aparc.stats(Right Hemisphere)
Tab Separated Variables JADNI_freesurfer.zip
Cortical Parcellation containing Thickness of Specific Structures based on Broadman Area Map llh.BA.stats(Left Hemisphere)
rh.BA.stats(Right Hemisphere)
Tab Separated Variables JADNI_freesurfer.zip
Cortical Parcellation containing Curvature for Cortical Thickness lh.curv.stats(Left Hemisphere)
rh.curv.stats(Right Hemisphere)
Tab Separated Variables JADNI_freesurfer.zip
Cortical Parcellation containing Thickness of Entorhinal Cortex lh.entorhinal_exvivo.stats(Left Hemisphere)
rh.entorhinal_exvivo.stats(Right Hemisphere)
Tab Separated Variables JADNI_freesurfer.zip
Subcortical Segmentation containing White Matter Parcellation Volumes wmparc.stats Tab Separated Variables JADNI_freesurfer.zip


5. PET Scan (FDG and Amyloid (PIB, BF227))

5.1 Quality Control

CRF NameCRF DescriptionFile Name File Format(Extension)ZIP File Name
PETQC PET Scan Information PETQC-J-ADNI.tsv Tab Separated Variables (.tsv) JADNI_petpc.zip

※ See J-ADNI_PETQC_Ver1.1.pdf and PET Scanner list for PET quality control procedures.

5.2 PET Images

DescriptionFile Name File Format(Extension)ZIP File Name
PET Images(Post-processed) See File_list_J-ADNI.pdf Analyze image file format (.hdr/.img) JADNI####_pet.zip



Principal Investigator:  Takeshi Iwatsubo

Affiliation: Department of Neuropathology, Graduate School of Medicine, the University of Tokyo

Project / Group Name: Japanese Alzheimer's disease neuroimaging initiative (J-ADNI)  (List of Authors, Citation Information)

Funds / Grants (Research Project Number): 

NameTitleProject Number

New Energy and Industrial Technology Development Organization of Japan (NEDO)

Translational Research Promotion Project

Research Project for the Development of a Systematic Method for the Assessment of Alzheimer's Disease 20100000001577

Health Labour Sciences Research Grant

Research on Dementia

Multisite longitudinal study for the evaluation of clinical manifestation and progression of Alzheimer disease: J-ADNI core study H19-Dementia Research-024

Health Labour Sciences Research Grant

Research on Dementia

J-ADNI core study: analysis and application of imaging biomarkers and establishment of clinical study network H22-Dementia Research-009
Life Science Database Integration Project (Database Integration Coordination Program) of Japan Science and Technology Agency

Study on integration of the human brain related diseases imaging data




TitleDOIData Set ID
1 Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials. doi: 10.1016/j.jalz.2018.03.009 JGAD00000000051


USERS (Controlled-Access Data)

Principal Investigator: Affiliation: Data in Use (Data Set ID)Period of Data Use
Michael C Donohue University of Southern California, Alzheimers Therapeutic Research Institute JGAD00000000051 2016/03/30-2017/12/31
Ryuichi Takahashi Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Department of Neurology JGAD00000000051 2016/04/27-2018/02/28
Kenji Ishii Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Neuroimaging Research Team JGAD00000000051 2016/05/02-2019/03/31
Hiroshi Matsuda National Center of Neurology and Psychiatry, Integrative Brain Imaging Center JGAD00000000051 2016/06/01-2020/03/31
Weining Robieson AbbVie JGAD00000000051 2016/08/04-2019/06/15
Michio Senda Division of Molecular Imaging, Institute of Biomedical Research and Innovation JGAD00000000051 2016/08/04-2019/03/31
Ken Aoshima hhc Data Creation Center, Eisai Co., Ltd. JGAD00000000051 2016/10/01-2019/03/31
Takashi Kato Department of Radiology, National Center for Geriatrics and Gerontology JGAD00000000051 2016/10/14-2022/03/31
Masashi Kikuchi MSD K.K. Japan Development Clinical Research Neuroscience Group JGAD00000000051 2016/10/12-2020/03/31
Hiroshi Suzuki Department of Pharmacy, The University of Tokyo Hospital JGAD00000000051 2017/01/11-2021/12/18
Masayasu Okochi Department of Psychiatry, Osaka University Graduate School of Medicine JGAD00000000051 2017/02/02-2021/12/10
Joyce Suhy Bioclinica, Inc. JGAD00000000051 2017/04/04-2019/11/21
Toshiharu Suzuki Faculty of Pharmaceutical Sciences, Hokkaido University JGAD00000000051 2017/05/02-2021/03/31
Danielle Harvey UC Davis, Division of Biostatistics JGAD00000000051 2017/05/02-2020/04/14
Jae-Won Jang Department of Neurology, Kangwon National University Hospital JGAD00000000051 2017/05/02-2017/10/13
Masayuki Sasaki Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University JGAD00000000051 2017/06/21-2022/03/31
Akihiko Shiino Molecular Neuroscience Research Center, Shiga University of Medical Science JGAD00000000051 2017/06/30-2018/05/31
Kiyoto Kasai Department of Neuropsychiatry, the University of Tokyo Hospital JGAD00000000051 2017/07/19-2020/11/28
Yuanzhong Li Imaging Technology Center, FUJIFILM Corpration JGAD00000000051 2017/09/05-2022/05/31
Atsushi Iwata Department of Neurology, the University of Tokyo Hospital JGAD00000000051 2017/09/21-2022/03/31
Tosimasa Yamamoto Saitama Medical University Neurology JGAD00000000051 2017/09/14-2020/09/01
Kazushi Suzuki Unit for early and exploratory development, the University of Tokyo Hospital JGAD00000000051 2017/10/11-2022/06/30
Tsukasa Funane Hitachi, Ltd., Research & Development Group, Center for Exploratory Research JGAD00000000051 2017/12/11-2020/03/31
Tadanori Fukami Graduate school of science and engineering, Yamagata University JGAD00000000051 2017/12/26-2020/03/31
Shuhei Yamaguchi Department of Internal Medicine III, Faculty of Medicine, Shimane University JGAD00000000051 2018/01/09-2022/03/31
Manabu Ishida ERISA Co., Ltd. JGAD00000000051 2018/01/09-2022/03/31
Tetsutaro Ono

Dai Nippon Printing Co., Ltd.

Communication & Information Center / Information Innovation Operations

JGAD00000000051 2018/04/20-2022/03/31
Sayuri Watanabe Janssen pharmaceutical K.K, R&D, Clinical science division JGAD00000000051 2018/06/07-2023/05/01
Eric Westman Karolinska Institutet, NVS Department, Division of Clinical Geriatris JGAD00000000051 2018/09/11-2021/09/01
Nancy Maserijian Biogen JGAD00000000051 2018/10/04-2021/12/31