NBDC Research ID: hum0027.v1



Aims : To identify polymorphisms (SNP and Indel) of responsible genes for Japanese aggressive periodontitis by whole exon sequencing (WES) analysis. Then, functional analyses forf the responsible genes were assessed by in vivo/vitro biological experiments.

Methods : WES by using of HiSeq 2000 (Illumina).

Materials : 44 Japanese aggressive periodontitis patients


Data Set IDType of DataCriteriaRelease Date



NGS (Exome) Controlled Access (Type I) 2016/07/28

*Release Note

* Data users need to apply the Form 2 (Application Form for Using NBDC Human Data) to reach the Controlled Access Data. Learn more



JGAS00000000024 and JGAS00000000040

Materials 44 Japanese aggressive periodontitis patients
Targets Exome
Target Loci for Capture Methods -
Platform Illumina [HiSeq 2000]
Library Source gDNA extracted from peripheral blood cells
Cell Lines -
Library Construction (kit name) Agilent SureSelect Human All Exon V5 (50M) kit
Fragmentation Methods Ultrasonic fragmentation (Covaris E220)
Spot Type Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers) 150 bp
DDBJ Sequence Read Archive ID

JGAD00000000024 (hg18)

JGAD00000000040 (hg19)

Total Data Volume 460 GB (fastq, bam, vcf)
Comments (Policies)

NBDC policy

Academic Use Only (till 2017/07/28)



Principal Investigator: Shinya Murakami

Affiliation: Division of Oral Biology and Disease Control, Department of Periodontology, Osaka University Graduate School of Dentistry

Project / Groupe Name:

URL: http://www.dent.osaka-u.ac.jp/english/g_school/facilities/periodontology.html

Funds / Grants (Research Project Number):

NameTitleProject Number
KAKENHI Grant-in-Aid for Scientific Research (A) Identification of genetic risk factors on aggressive periodontitis in a Japanese population 15H02579
KAKENHI Grant-in-Aid for Scientific Research (C) Effects of cathepsin A on the regeneration of periodontal tissue 15K11385



TitleDOIData Set ID
1 - - -