NBDC Research ID: hum0013.v1

 

SUMMARY

Aims: To build a Japanese control DNA database for application to genetic investigations on adverse drug reactions and facilitate in the development of drugs with high efficacy and safety.

Methods: Determine the genotype of nearly 2.5 million single nucleotide polymorphisms (SNPs) by using of illumina HumanOmni2.5-8.

Participants/Materials: 2994 Japanese healthy controls

URL: http://www.jpdsc.org/  *See also

 

Data Set IDType of DataCriteriaRelease Date
hum0013.v1.freq.v1 genotype counts of 2.5 million SNPs Un-restricted Access 2014/10/16

*Release Note

 

MOLECULAR DATA

hum0013.v1.freq.v1

Participants/Materials 2994 Japanese healthy controls
Targets genome wide SNPs
Target Loci for Capture Methods -
Platform Illumina [HumanOmni2.5-8 BeadChip]
Source DNAs extracted from peripheral blood
Cell Lines -
Reagents (Kit, Version) HumanOmni2.5-8 v1.0 BeadChip Kit
Genotype Call Methods (softwares) GenomeStudio
Filtering Methods Call Rate ≧ 0.95 and HWE ≧ 0.001
Marker Number (after QC) 2,343,307 SNVs
NBDC Data Set ID

hum0013.v1.freq.v1

(Click the Data Set ID to download the file)

Dictionary file

Total Data Volume 68.9 MB (zip [txt])
Comments (Policies) NBDC policy

*When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more

 

DATA PROVIDER

Principal Investigator: Koji Suematsu

Affiliation: PGx, Clinical Research, Taisho Pharmaceutical Co., Ltd.

Project / Group Name: The Japan PGx Data Science Consortium (JPDSC)

URL: http://www.jpdsc.org/

Funds / Grants (Research Project Number):

NameTitleProject Number
- - -

 

PUBLICATIONS

TitleDOIData Set ID
1 Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. doi:10.2217/pgs.13.180 hum0013.v1.freq.v1
2 A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. doi:10.1038/tpj.2011.41 hum0013.v1.freq.v1